Ice is the Magic Medicine


Cryotherapy is the therapeutic use of locally applied coolants to affect various physiological processes through the cooling of soft tissues.  Cooling occurs when heat is removed or lost from an object through conduction of heat from one mass to another, or through  evaporation.  Conduction occurs when heat is transferred from a warm body to a colder body by direct contact between their surface molecules.  The slow moving molecules of the cold body speed up by absorbing energy from the faster moving molecules of the warm body, thereby becoming warmer, while, conversely, the faster moving molecules of the warm body slow down as they lose energy and become cooler. Conduction occurs when a cool mass (like ice) is applied continuously to the skin, or when a body part is immersed in cold water.  As the body or body part cools, the ice or cold water heats up.

Ice bag

Cryotherapy has historically been used to provide pain relief, reduce fever, slow the damage of thermal burns, control bleeding, and prevent or reduce edema caused by soft tissue trauma.  Cryotherapy has also been shown to be useful for the reduction of extrafusal and intrafusal  muscle spasm,  neuromuscular hypertonicity, and  spasticity. Cryotherapy may additionally be used to elevate the pain threshold and slow destructive enzyme action that occurs in some joint diseases.

Cold gel pack

Methods of Cryotherapy

1) Cold packs
2) Ice massage (over a small area)
3) Cold baths (for an entire extremity)
4) Vapocoolant Spray

Physiology behind Ice therapy

The cooling of bodily tissue is governed by two basic physiological principles:
(1) the cooling effect on the soft tissue by an ice massage or ice pack will decrease as the depth of the tissue increases;  (2) the time required for cooling to be effective will vary according to the type of tissue being cooled (the speed of cooling underlying tissues will decrease as the amount of insulating fat increases).

Ice bath of foot

As cooling decreases tissue temperatures, the sensory nerves in the skin are provoked to fire continuously until physiologically exhausted.  Usually this causes the subject to predictably experience a sequence of sensations including aching, burning, and finally numbness (though exceptions will be found).  Numbness or temporary local anesthesia occurs as the sensory nerves are exhausted and, coincidentally, when the normal erythema of the skin reaches its zenith.

Vapocoolant spray

Deeper nerves (below the epidermis) may also be affected by cooling.  Muscle cooling has been shown to affect the afferent nerves arising from the muscle spindle flower-spray and annulospiral sensory nerve endings.  Their rate of discharge decreases as the temperature of muscle tissue decreases.  As the temperature drops, the sensitivity of the muscle spindle initially  increases (a minimal stretch is required for a spindle response at 30°C), but as the temperature decreases further, the spindle's sensitivity decreases (requiring a bigger stretch to elicit a muscle spindle response).  Some evidence has suggested that cooling may affect a decrease in the rate of muscle spindle discharge by causing membrane hyper polarization with a lowering of  potassium concentration. Cooling may also affect the speed of impulse of the  gamma efferents to the muscle spindle by decreasing  gamma biasing of the muscle spindle  intrafusal muscle fiber,thereby depressing membrane activity and the stretch reflex.  This occurs in the muscle after 10 minutes of cooling with a crushed ice pack (if the muscle isn’t too deep).

Ice cube massage

Cooling of the exteroceptors of the skin has been shown to increase the amplitude of the H response (a phasic stretch reflex induced by electrical stimulation), largely by- passing the muscle spindle, by increasing or facilitating alpha motor neuron excitability.
As the temperature drops toward 5°C, there are decreases in the amplitude and frequencies of the motor endplate potentials combined with increases in their duration. If cooling is sufficient to drive the muscle tissue temperature at the neuromuscular junction down to 5°C, blockage of the junction has been shown to occur.

Cryotherapy unit

The effects of cooling on peripheral nerves are primarily dependent on myelination and fiber diameter.  All nerve fibers are generally affected by cooling.  The smaller medullated fibers are affected first, then the large medullated, and finally the non-medullated.  The smaller gamma efferent fibers are more sensitive to cold (their frequency slowing more quickly and to a greater extent) than are the  alpha efferents.
Motor nerve conduction velocity decreases linearly at a rate of between 1.84 and 2.4 meters per second per degree (centigrade), as the temperature drops from 36 to 23°C. Proprioceptive sensory fibers (and others important for motor learning) are relatively insensitive to cooling since they are large diameter myelinated fibers.

Latest mobile cryotherapy unit

Additionally, cooling has been shown to affect the various vascular structures at all levels to the extent of causing an initial reflex vasoconstriction to occur.  It is unclear what specifically causes vasoconstriction, but various reasons have been suggested.  One theory is that vasoconstriction occurs in tissues in which the cold induces an increase in the firing of sympathetic nerve fibers within the tissues cooled.  Another theory postulates that vasoconstriction occurs from the cooling of tissues by directly affecting the blood vessels themselves.

Whatever the specific mechanism may be, vasoconstriction has been shown to reduce blood flow in tissues cooled to 18°C.  As cooling continues, however, and the tissue temperature reaches 2°C, vasodilation occurs in a physiological attempt to  increase blood flow and thereby prevent tissue damage. This phenomenon is called the Lewis Hunting Reaction.

Hand immersed in ice

Cryotherapy has been shown to be extremely valuable when applied in combination with other modalities.  Ice packing, for example, may be used together with heat in the form of contrast packs to increase capillary bed circulation and to reduce joint stiffness.
The hot pack should last for 10 minutes followed by a three-minute ice pack.
The heat should then be reapplied for four minutes followed by another three-minute ice pack; this process should be repeated for a total treatment time of 30 minutes.

Research has demonstrated that the cooling of a joint results in vasoconstriction and a decrease in interarticular temperature.  This has the effect of slowing enzyme action and its destructive action. It has also been demonstrated that cryotherapy applied over the area of an over-stretched ligament may increase edematous swelling in the general area but decreases the edema around the injured ligament.

Applying ice pack 

Cryotherapy has been shown to have a rather dramatic effect on soft tissues because of the physiological responses it provokes.  As a result, it has become a valuable tool for the treatment of various physical dysfunctions.


Adverse effects of ice packing are rare, but some of the symptoms that may be associated with abnormally high histamine production triggered by cooling include cold urticaria, erythema, itching, sweating, and shortness of breath.  More severe symptoms may develop including syncope,  tachycardia,  extra systoles,  dysphagia,  abdominal cramping or diarrhea.  These symptoms may occur during therapy or soon after, but they have been known to appear several hours later.


Cold hemolysins and agglutinins produced in abnormal amounts in response to tissue cooling may produce significant anemia, malaise,  chills,  fever,  paroxysmal cold hemoglobinuria of the kidney, or the dermal symptoms of cold urticaria or ulcerations.

Abnormally high cryoglobulin production in response to cooling may produce chills and fever and may adversely affect vision and hearing (blindness or deafness in the extreme).  It may cause conjunctival hemorrhages and epistaxis,  anemia with fibrinogenopenia, elevated sedimentation rates, and abnormal numbers of cryoglobulin inclusion cells. Other symptoms include itching,  purpura,  cold urticaria,  ulcerations and necrosis, dyspnea, stomatitis, melena, and bleeding of the gums.

Ice burn

Cryotherapy may be contraindicated for open wounds.  The use of a cryotherapeutic application should be based on the extent, nature, depth of the wound, and the chances of contamination.  Advantages must be weighed against the risks.  For example, there is little risk and a great deal of benefit to be gained by cooling a freshly contused area, in spite of the presence of a shallow wound.  It may be helpful in slowing or stopping bleeding if a dry sterilized ice bag is used or if the treatment site is protected from the touch of any water (a plastic bag may be helpful).  However, cryotherapeutic applications may further damage involved tissues if the wound is deep or the vasocirculation in the area is impaired through application.


1) Cold urticaria
3)Raynaud’s phenomenon

Raynaud’s phenomenon

4)Paroxysmal cold hemoglobinuria
5)Peripheral vascular disease

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